检索范围:
排序: 展示方式:
Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 697-706 doi: 10.1007/s11684-018-0655-7
Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome.
关键词: resveratrol reactive oxygen species AMPK mTOR autophagy
Mechanisms of insulin resistance in obesity
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 14-24 doi: 10.1007/s11684-013-0262-6
Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin resistance. In those hypotheses, inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of attention. Oxidative stress, endoplasmic reticulum (ER) stress, genetic background, aging, fatty liver, hypoxia and lipodystrophy are active subjects in the study of these concepts. However, none of those concepts or views has led to an effective therapy for type 2 diabetes. The reason is that, there has been no consensus for a unifying mechanism of insulin resistance. In this review article, literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance, in which insulin resistance is a result of energy surplus in cells. The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Decreasing ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin resistance. In support, many of existing insulin sensitizing medicines inhibit ATP production in mitochondria. The effective therapies such as weight loss, exercise, and caloric restriction all reduce ATP in insulin sensitive cells. This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity, which may apply to insulin resistance in aging and lipodystrophy.
关键词: type 2 diabetes energy expenditure inflammation lipotoxicity mitochondria hyperinsulinemia adenosine monophosphate-activated protein kinase (AMPK)
Mechanism of insulin resistance in obesity: a role of ATP
《医学前沿(英文)》 2021年 第15卷 第3期 页码 372-382 doi: 10.1007/s11684-021-0862-5
关键词: type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK
Autophagy and the nutritional signaling pathway
Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI
《农业科学与工程前沿(英文)》 2016年 第3卷 第3期 页码 222-230 doi: 10.15302/J-FASE-2016106
关键词: Autophagy ULK1 complex VPS34 complex AMPK mTOR nutrient signaling
标题 作者 时间 类型 操作
Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR
Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia
期刊论文